The principle of proton knife is to use a positively charged proton in the electric field to continue to accelerate to reach a certain speed and energy, the incident into the subject matter, the use of Bragg Peak phenomenon, a specific object within a depth of the release A large amount of energy to achieve the purpose of destroying the specific depth of the object. Protons are a commercial application of proton accelerators, and early proton accelerators are used in particle physics to accelerate protrusions to discover new particles; the world's largest proton accelerator is located at the European Nuclear Research Center (CERN). At present, mature proton accelerator technology is applied to many different industries areas.
In the medical tumor radiotherapy used on the proton therapy, mostly by the carbon atoms of the nucleus made of heavy particle proton accelerator, because it carries more energy, the treatment effect is more significant. In the actual treatment, the proton knife to three degrees of space aimed at the patient's tumor location, through the energy carrying protons at a specific depth will release most of the energy of the Prague spike phenomenon, a lot of energy released in the tumor (cancer lesion area). In order to achieve the destruction of cancer cells in the tumor without destroying the tumor outside the other normal cells, and even the final elimination of the purpose of the tumor. Compared to the traditional X-ray radiotherapy or gamma knife, photon knife and other treatment, proton knife treatment of the lesion around the normal cell damage is much smaller, relatively less side effects. Proton knife treatment for the current world's most advanced tumor radiotherapy technology, but the proton knife as the main equipment of the proton therapy center because the cost is very expensive, until 2012 the world has set up only about 40 proton therapy center, A total of about 70,000 patients were treated. China's first proton therapy center began clinical use in December 2004 and Taiwan's first proton therapy center in 2014 began clinical use.